Month: November 2017

Effects on Bivalves and Associated Ecology in the Chukchi Sea Due to Changing Sea Ice Conditions

The Arctic Ocean sea ice extent has been rapidly declining since 1979. Positive feedback loops are expected to increase the rate of melting, posing a serious threat to the entire Arctic marine ecosystem. The Arctic Ocean ecosystem, including the Chukchi Sea, is currently benthic dominated, but is expected to become pelagic dominated due to changes in algal and zooplankton dominance.

The Molecular Basis for the Broad Substrate Specificity of Human Sulfotransferase 1A1

The cytosolic sulfotransferase (SULTs) family catalyzes the transfer of a sulfate group from the universal 3′-phosphoadenosine 5′-phosphosulfate (PAPS) donor to a wide variety of acceptor molecules bearing a hydroxyl or an amine group [1], [2], [3]. Sulfonation results in inactivation of the majority of acceptors, including neurotransmitters, steroid hormones and drugs, thus modulating their biological activity and rendering the product more soluble and readily excretable.

Pancreatic Cancer Cells during Metastatic Progression

Our research focused on the detection of premalignant pancreatic cancer via computational analysis of serum proteomic profiles.

Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation

Interleukin-6 (IL-6) is a pleiotropic cytokine with important functions in many physiological and pathophysiological conditions. IL-6 activates intracellular signaling cascades through a homodimer of the ubiquitously expressed β-receptor glycoprotein 130 (gp130) but first has to bind to its nonsignaling alpha receptor (IL-6R). The IL-6R is expressed in a cell- and tissue-specific manner and only found on hepatocytes and some leukocytes like neutrophils and T cells.

Novel Hybrid Polymer Composite

A novel low cost hybrid polymer composite, using coir dust and fly ash particle reinforcements is proposed in this paper. Investigation of the dielectric behavior of this hybrid polymer composite proves its potential as a marketable product.

Jamb and Jamc Muscle in on Myoblast Fusion

Dashing down a track, sprinters rely on the special properties of the fast-twitch muscle fibers interspersed throughout their skeletal muscles. Meanwhile, long-distance runners are more concerned with performance of the slow-twitch muscle fibers in those same muscles. In humans, these fibers differ in the number of mitochondria they contain, but both types of muscle are formed from a cellular syncytium: many muscle cells fuse together into a multinucleate mass.

Integrated Electron Microscopy: Super-Duper Resolution

Since its inception, electron microscopy (EM) has revealed that cellular membranes are organized into structurally distinct subdomains, created by localized protein and lipid assemblies to perform specific complex cellular functions. Caveolae are membrane subdomains that function as signaling platforms, endocytic carriers, sensors of membrane tension, and mechanical stress, as well as in lipid homeostasis.

The Long-Range Effects on Locally Important Marine Resources

Kotzebue, Alaska, a tiny city perched on the Baldwin Peninsula, is thirty-three miles above the Arctic Circle. Kotzebue is bordered by the Kotzebue Sound to the west and the Hotham Sound to the east. These two bodies of water both join into the Chucki Sea.

Methods of Reusing Food Waste

The development of an algorithm through the assessment of nutrients in a recycled food supplement for canines.

Protein Oxidation Implicated as the Primary Determinant of Bacterial Radioresistance

The amount of DNA damage caused by a given dose of γ-radiation for resistant and sensitive bacteria is very similar. Yet, the range of ionizing radiation (IR) resistances is large, with a factor of 200 separating the most-resistant from the most-sensitive species. For example, Deinococcus radiodurans can survive levels of IR (10 kGy) that induce approximately 100 DNA double-strand breaks (DSBs) per genome, whereas Shewanella oneidensis is killed by levels of IR (0.07 kGy) that result in less than 1 DSB per genome.

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