Our research focused on the detection of premalignant pancreatic cancer via computational analysis of serum proteomic profiles.
Interleukin-6 (IL-6) is a pleiotropic cytokine with important functions in many physiological and pathophysiological conditions. IL-6 activates intracellular signaling cascades through a homodimer of the ubiquitously expressed β-receptor glycoprotein 130 (gp130) but first has to bind to its nonsignaling alpha receptor (IL-6R). The IL-6R is expressed in a cell- and tissue-specific manner and only found on hepatocytes and some leukocytes like neutrophils and T cells.
Pollutants that resist breakdown and accumulate in the food chain are of great concern because they are consumed or absorbed by fish and other marine wildlife, which in turn are consumed by humans (NOAA, 2003). One of the most dangerous and controversial contaminants today is tributyltin (TBT). Tributyltin is one of the most poisonous substances to be released to the aquatic environment (Knutzen, 1995). It is used in many of the world’s marine paints to keep barnacles, seaweed, and other organisms from clinging to ships.
Modification of protein function by phosphorylation controls many aspects of cellular function and signaling. Interestingly, the first evidence for phosphoproteins came from the observation that the secreted milk protein, casein, contained phosphate, suggesting that phosphorylation can occur in the extracellular space.
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