Month: April 2019

Comparative genomics of the tardigrades Hypsibius dujardiniand Ramazzottius varieornatus

The superphylum Ecdysozoa emerged in the Precambrian, and ecdysozoans not only dominated the early Cambrian explosion but also are dominant (in terms of species, individuals, and biomass) today. The relationships of the 8 phyla within Ecdysozoa remain contentious, with morphological assessments, developmental analyses, and molecular phylogenetics yielding conflicting signals.

Gene Involvement in Sensorineural Hearing Loss

Sensorineural hearing loss is a serious impairment that deprives more than 360 million people worldwide from one of their vital senses. Though common, this medical disability has no cure yet. However, gene therapy is an emerging treatment that is being developed to tackle the root causes of this morbidity.

Design Principles of the Yeast G1/S Switch

A hallmark of the G1/S transition in budding yeast cell cycle is the proteolytic degradation of the B-type cyclin-Cdk stoichiometric inhibitor Sic1. Deleting SIC1 or altering Sic1 degradation dynamics increases genomic instability. Certain key facts about the parts of the G1/S circuitry are established: phosphorylation of Sic1 on multiple sites is necessary for its destruction, and both the upstream kinase Cln1/2-Cdk1 and the downstream kinase Clb5/6-Cdk1 can phosphorylate Sic1 in vitro with varied specificity, cooperativity, and processivity.

Constructing Silver Nanoparticles

Each year, over two million new cases of skin cancer are diagnosed, which is greater than the combined incidence of cancers of the breast, prostate, lung and colon. Therefore, prevention of skin cancer from the harmful effects of UV remains a priority area of research.

Col V siRNA Engineered Tenocytes for Tendon Tissue Engineering

Tendons and ligaments are frequently targets of injury from trauma in sports and aging [1], [2]. It is well known that tendons and ligaments do not heal through a regenerative process; Instead, their healing occurs via the formation of a fibrotic scar [3]–[5]. In the healing tendon, a uniform distribution of small diameter collagen fibrils has been found with poorer mechanical properties than native tissue and shows no improvement of mechanical properties with time.

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