Month: September 2019

Integrated Time-Lapse and Single-Cell Transcription Studies Highlight the Variable and Dynamic Nature of Human Hematopoietic Cell Fate Commitment

Hematopoietic stem and progenitor cells (HSPCs) give rise to all the cellular components of blood. The major stages of differentiation and the key genes participating in this process are now well characterised [1]. According to the classical view, haematopoiesis is a hierarchically organised process of successive fate commitments, in which differentiation potential is progressively restricted in an orderly way over cell divisions.

Superfamily Assignments for the Yeast Proteome through Integration of Structure Prediction with the Gene Ontology

The yeast Saccharomyces cerevisiae is one of the most widely studied organisms, yet a large fraction of its proteins are of unknown structure and/or unknown function. Knowledge of the structure of a protein is critical to understand how it functions, and hence, a complete set of protein structures for yeast is desirable, but difficult to accomplish experimentally.

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