Ribosome Traffic on mRNAs Maps to Gene Ontology: Genome-wide Quantification of Translation Initiation Rates and Polysome Size Regulation
The expression of genes can be considered as a two-stage process, beginning with transcription and the production of an mRNA, followed by translation of that mRNA into protein by the cell’s ribosome population. Gene expression must be tightly regulated to control protein composition, enabling the cell to rapidly respond to a wide range of environmental conditions. For this reason, cells exert fine control over gene expression, both at the transcriptional, and post-transcriptional level.
