The Road Not Taken: Could Stress-Specific Mutations Lead to Different Evolutionary Paths?
The evolutionary trajectories of organisms are paved with mutations, which generate the raw material (genetic variation) essential for evolutionary change. In biology class, we learn that mutations are random: the probability that a mutation occurs is independent of its fitness effect (i.e., its impact on individual survival or reproduction). As Luria and Delbruck famously showed [1], bacterial mutations that confer resistance to a virus continually arise in a population before exposure to the virus; under subsequent viral infection, these mutations spread in the population.