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In Vitro Model of Vascularized Bone: Synergizing Vascular Development and Osteogenesis

In native bone, synergistic interactions between osteoblasts/osteogenic precursors and endothelial cells enable coordinated development of vasculature and mineralized tissue. In the process of intramembranous ossification during craniofacial bone growth, this cell coupling results in close spatial relationships between the two tissues in newly forming bone, with the vascular network serving as a ‘template’ for bone mineral deposition [1]. A synergy between the two cell populations has also been observed during endochondral ossification.

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In Vitro Model of Vascularized Bone: Synergizing Vascular Development and Osteogenesis

In native bone, synergistic interactions between osteoblasts/osteogenic precursors and endothelial cells enable coordinated development of vasculature and mineralized tissue. In the process of intramembranous ossification during craniofacial bone growth, this cell coupling results in close spatial relationships between the two tissues in newly forming bone, with the vascular network serving as a ‘template’ for bone mineral deposition [1]. A synergy between the two cell populations has also been observed during endochondral ossification.

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In Vitro Model of Vascularized Bone: Synergizing Vascular Development and Osteogenesis

In native bone, synergistic interactions between osteoblasts/osteogenic precursors and endothelial cells enable coordinated development of vasculature and mineralized tissue. In the process of intramembranous ossification during craniofacial bone growth, this cell coupling results in close spatial relationships between the two tissues in newly forming bone, with the vascular network serving as a ‘template’ for bone mineral deposition [1]. A synergy between the two cell populations has also been observed during endochondral ossification.

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