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A fat-derived metabolite regulates a peptidergic feeding circuit in Drosophila

Animals must balance food intake with energy expenditure to maintain optimal health. In choosing what and how much to eat, animals integrate external cues like tastes and smells with internal motivational states like hunger and satiety. Powerful homeostatic mechanisms tie these motivational states to the sensing of nutrient and energy status. Because fat is the primary long-term energy storage molecule, these homeostatic sensors monitor fat levels—triggering increased feeding when they fall and decreased feeding when they rise.

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A fat-derived metabolite regulates a peptidergic feeding circuit in Drosophila

Animals must balance food intake with energy expenditure to maintain optimal health. In choosing what and how much to eat, animals integrate external cues like tastes and smells with internal motivational states like hunger and satiety. Powerful homeostatic mechanisms tie these motivational states to the sensing of nutrient and energy status. Because fat is the primary long-term energy storage molecule, these homeostatic sensors monitor fat levels—triggering increased feeding when they fall and decreased feeding when they rise.

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A fat-derived metabolite regulates a peptidergic feeding circuit in Drosophila

Animals must balance food intake with energy expenditure to maintain optimal health. In choosing what and how much to eat, animals integrate external cues like tastes and smells with internal motivational states like hunger and satiety. Powerful homeostatic mechanisms tie these motivational states to the sensing of nutrient and energy status. Because fat is the primary long-term energy storage molecule, these homeostatic sensors monitor fat levels—triggering increased feeding when they fall and decreased feeding when they rise.

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