Col V siRNA Engineered Tenocytes for Tendon Tissue Engineering

Tendons and ligaments are frequently targets of injury from trauma in sports and aging [1], [2]. It is well known that tendons and ligaments do not heal through a regenerative process; Instead, their healing occurs via the formation of a fibrotic scar [3]–[5]. In the healing tendon, a uniform distribution of small diameter collagen fibrils has been found with poorer mechanical properties than native tissue and shows no improvement of mechanical properties with time.

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