In-Silico Patterning of Vascular Mesenchymal Cells in Three Dimensions
The evolution of tissue form in development, wound healing, and regeneration is a dynamic process that involves the integration of local cues on cell fate and function. These cues include interactions with soluble factors (growth factors, morphogens, dissolved gases) and insoluble factors (extracellular matrix, neighboring cells) in a three-dimensional context. A fundamental understanding of how tissue structure evolves is critical to the rational development of engineered tissues for therapeutic applications.