Biology

Quantification of Atherosclerosis

Atherosclerosis and subsequent cardiovascular disease causes nearly one-third of all deaths in the world. Unfortunately, atherosclerosis commonly remains asymptomatic for decades, and is properly diagnosed only after a severe, life-threatening cardiac event. Thus, a portable, low‐cost tattoo‐based biosensor for the non‐invasive self‐diagnosis and quantification of atherosclerosis was developed.

Cell Line to Search for Osteosarcoma Agents

Osteosarcoma, a bone tumor of childhood, is lethal when unresponsive to chemotherapy. ER stress response, a cell survival mechanism that is triggered upon exposure to stressors such as chemotherapy, is one of the ways a tumor becomes resistant to chemotherapy. This project explores novel methods of producing a noncytotoxic EGFP-ATF6 construct to signal Endoplasmic Reticulum stress response.

Ultrasound for Autonomous Heart Attacks

Every year, half of the 610,000 heart attack deaths in the United States are due to a lack of prompt medical attention. Currently, most technologies fail to fix the problem, as they simply take too long to be able to detect a heart attack in time.

Translational Genomics of Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) does not respond to receptor targeted treatments because they do not possess the ligands to bind to these receptors. Thus, more research needs to be explored in terms of the translational modifications that genes undergo during this disease.

Phytoplankton Plastid Proteomics & Biochemistry

The global epidemic of increased carbon dioxide (CO2) in the atmosphere has brought many researchers together in an attempt to find a solution. One such idea for sequestering CO2 out of the atmosphere is to employ phytoplankton, a dominant oceanic primary producer.

Diabetic Retinopathy via Hypertensive Modeling

This interdisciplinary study develops a novel prognostic for Diabetic Retinopathy (DR) by modeling hypertensive changes at arterial-venous (AV) crossings

Cancer Stem Cells in Oral Squamous Cell Carcinoma

Oral Squamous Cell Carcinoma (OSCC) is a cancer of the mouth epithelium with an annual incidence rate in the US of nearly 48,000 cases annually and a 5-year survival rate of only 65%. Cancer stem cells (CSCs) are believed to be responsible for progression of OSCC. The project’s main goal is to observe the effect of Wnt/β-catenin signaling inhibition on oral squamous cell carcinoma.

Unraveling Complexities of Alzheimer’s Disease

Alzheimer’s is a neurodegenerative disease characterized by the formation of extracellular amyloid-beta (abeta or AB) plaques and intracellular tau plaques. This experiment explores whether the presence of normal tau-441 protein augments AB-42 aggregation.

Gene Involvement in Sensorineural Hearing Loss

Sensorineural hearing loss is a serious impairment that deprives more than 360 million people worldwide from one of their vital senses. Though common, this medical disability has no cure yet. However, gene therapy is an emerging treatment that is being developed to tackle the root causes of this morbidity.

Constructing Silver Nanoparticles

Each year, over two million new cases of skin cancer are diagnosed, which is greater than the combined incidence of cancers of the breast, prostate, lung and colon. Therefore, prevention of skin cancer from the harmful effects of UV remains a priority area of research.

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