Spatial Learning Depends on Both the Addition and Removal of New Hippocampal Neurons

It was classically assumed that once the development of the central nervous system ended, “everything can die, nothing can regenerate and be renewed”. This dogma, restricting neurogenesis to a developmental phenomenon has, however, been challenged by the discovery that new neurons are created in specific regions of the adult mammalian brain.

Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies

Synapses undergo age-associated morphological and functional changes in a number of model organisms and in humans. In the fruit fly Drosophila melanogaster and the worm Caenorhabditis elegans, synaptic changes were seen during normal aging in both central and peripheral parts of the nervous system and linked to cognition, memory, learning, locomotor, and homeostatic deficits.

Novel Hybrid Polymer Composite

A novel low cost hybrid polymer composite, using coir dust and fly ash particle reinforcements is proposed in this paper. Investigation of the dielectric behavior of this hybrid polymer composite proves its potential as a marketable product.

Post-MI Cardiac Tissue Engineering

In this study, the author engineers novel gelatin-NIPAM-graphene hydrogels and new, powerful computational tools to enhance precision cardiovascular medicine. Engineering Injectable, Conductive Hydrogels doped with Graphene and Graphene Oxide Nanoparticles for Post-MI Cardiac Tissue Engineering and Robust Drug Discovery: A Computationally-Aided Investigation for Enhancing Therapeutic Efficacy

Smartphone-based Ophthalmic Screening for Glaucoma

Lumos can allow patients to quickly screen for glaucoma and detect the disease in its early stages. All the patient needs is a smartphone, and the app will identify the glaucoma risk rapidly and automatically.

OmniChange: The Sequence Independent Method for Simultaneous Site-Saturation of Five Codons

Directed evolution and rational design are two complementing and often synergistic approaches for tailoring biocatalyst properties to application demands

Dynamic Response of a Human Neck Replica to Axial-Compression Impact Loading

A human neck replica was made to simulate dynamic response to axial loading, H1. Dynamic loading of neck replica can simulate realistic axial-compression injury to the cervical spine. H2. Severity of measured neck force depends upon impact load and velocity. H3. Neck flexion-extension position affects measured neck force. H4. Simulated neck musculature affects neck stability.

How to Change the Oligomeric State of a Circular Protein Assembly: Switch from 11-Subunit to 12-Subunit TRAP Suggests a General Mechanism

Multisubunit circular proteins play key roles in a variety of biological mechanisms. A number of proteins including bacterial toxins [1], viral portal proteins [2], flagellar motor proteins [3], [4], Sm-like proteins [5], components of the type III secretion system [6] and protective antigen of anthrax toxin [7], [8] can form circular oligomers with alternative oligomeric states. In some cases, for example for the viral portal proteins, a single functional oligomeric state is found in vivo and it is not known if the alternative oligomeric states are active.

Powering Wearable Microelectronics

Wearable low power biometric devices and body sensor network systems (BSNs) such as heart, respiration, and activity monitors are popular devices that are predicted to increase tenfold by 2018. This project focused on biomechanical energy harvesting from rib cage expansion using piezoelectric materials and frequency up conversion to power wearable microelectronics.

Creating Advanced Body Armor by Combining Web Geometry with Shear Thickening Fluids

Body armor is currently created using geometry based on Kevlar fabric. This research focuses on determining how to make the design stronger and more effective by using several combinations and strength thickening fluids.

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