Place field assembly distribution encodes preferred locations

The hippocampus mediates the formation of adaptive memory for positive or negative experiences, but the neurophysiological mechanisms of this learning process remain unknown. The hippocampus may encode locations independently from the stimuli and events that are associated with these locations.

Design Principles of the Yeast G1/S Switch

A hallmark of the G1/S transition in budding yeast cell cycle is the proteolytic degradation of the B-type cyclin-Cdk stoichiometric inhibitor Sic1. Deleting SIC1 or altering Sic1 degradation dynamics increases genomic instability. Certain key facts about the parts of the G1/S circuitry are established: phosphorylation of Sic1 on multiple sites is necessary for its destruction, and both the upstream kinase Cln1/2-Cdk1 and the downstream kinase Clb5/6-Cdk1 can phosphorylate Sic1 in vitro with varied specificity, cooperativity, and processivity.

Dynamic Response of a Human Neck Replica to Axial-Compression Impact Loading

A human neck replica was made to simulate dynamic response to axial loading, H1. Dynamic loading of neck replica can simulate realistic axial-compression injury to the cervical spine. H2. Severity of measured neck force depends upon impact load and velocity. H3. Neck flexion-extension position affects measured neck force. H4. Simulated neck musculature affects neck stability.

Large-Scale Bi-Level Strain Design Approaches and Mixed-Integer Programming Solution Techniques

Metabolic engineering of microbial strains has been of great interest for producing a wide variety of chemicals including biofuels, polymer precursors, and drugs. While conventional metabolic engineering approaches often focus on modifications to the desired and neighboring pathways, recent developments in computational analysis of metabolic models allow identification of genetic modifications needed to improve production of biochemicals

Integration of individual and social information for decision-making in groups of different sizes

When making decisions in a group, individuals can adapt their initial beliefs according to the social influence produced by the opinions of other individuals in the group. In modern society, this type of process is widespread and can be seen in settings ranging from work meetings to the courtroom.

Increasing Efficiency of Preclinical Research By Group Sequential Designs

Group sizes in preclinical research are seldom informed by statistical power considerations but rather are chosen on practicability [1, 2]. Typical sample sizes are small, around n = 8 per group (, and are only sufficient to detect relatively large sizes of effects. Consequently, true positives are often missed (false negatives), and many statistically significant findings are due to chance (false positives).

Flight Speeds among Bird Species: Allometric and Phylogenetic Effects

A full evaluation of the applicability of aerodynamic scaling rules must be based, not on theoretically derived speeds, but on empirical measurements of airspeeds of a wide variety of bird species in natural cruising flight. Here, we present tracking radar measurements of flight speeds of 138 species from six main monophyletic groups, which were analysed in relation to biometry (m, S, and wingspan b) and evolutionary origin (as reflected by phylogenetic group).

Developing a New Search for Randomly Accessible Data

There are only two widely-used searches for randomly accessible data: linear search and binary search. I developed and created a new search and tested it against binary search, linear search, and variations of them.

Improving Status Quo Rationale to Improve Middle Income Households

This study demonstrates correlation between economic trends and changes in markets. They also show that CAPE downside management is effective in combination with a delay and dynamic asset allocation.

A New Discrete Dynamic Model of ABA-Induced Stomatal Closure Predicts Key Feedback Loops

The epidermes of leaves and other aerial plant parts have natural openings known as stomata. Stomata are the entry and exit points where gas exchange, particularly CO2 uptake for photosynthesis and O2 and water vapor diffusion from the leaf interior to the atmosphere, takes place. Each stomate is surrounded by a pair of guard cells that modulate stomatal apertures in response to endogenous water status, to multiple phytohormones, and to many environmental signals such as light and CO2 [1–4].

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