Post-MI Cardiac Tissue Engineering

In this study, the author engineers novel gelatin-NIPAM-graphene hydrogels and new, powerful computational tools to enhance precision cardiovascular medicine. Engineering Injectable, Conductive Hydrogels doped with Graphene and Graphene Oxide Nanoparticles for Post-MI Cardiac Tissue Engineering and Robust Drug Discovery: A Computationally-Aided Investigation for Enhancing Therapeutic Efficacy

Method of Targeting Circulating Tumor Cells

Cancer metastasis accounts for 90% for all cancer-related deaths. Thus, treatment and prevention of secondary tumor formation is vital. A liposome coated with an adhesion molecule and death ligand is proposed in order to target the cancer cells in the bloodstream.

Using Adhesion Molecules to Separate Circulating Tumor Cells

Circulating tumor cells (CTCs) have a characteristic identification in metastasis. In order to monitor, diagnose, and analyze early-stage non-hematologic cancers, these rare cells must be separated from the whole blood with high efficiency. Thus, a microfluidic chip coated with E-selectin and microscopic inclined three-dimensional groove and wave patterns, which increases the probability of cell contact and separates the leukocytes and CTCs even further, is created.

Examining the Zika Virus

This research focuses on creating a novel rapid diagnostic test for Zika Virus NS1 protein using nanoribbon microfluidics.

Understanding Patient-Derived Glioblastoma Multiforme Cells’ Proliferation

Glioblastoma multiforme (GBM) is the most common and aggressive type of primary brain tumor. Patients with GBM have a median survival of 15 months. Thus, treating GBM can be achieved by inhibiting the proliferation of the patient-derived cells using leaf extract of B. monnieri.

Smartphone-based Ophthalmic Screening for Glaucoma

Lumos can allow patients to quickly screen for glaucoma and detect the disease in its early stages. All the patient needs is a smartphone, and the app will identify the glaucoma risk rapidly and automatically.

Lab-On-A-Chip Device for Disease Diagnostics

RNA-based viruses and bacteria have been sources of large-scale epidemics and pandemics, most notably Ebola, SARS, influenza, hepatitis C, HIV, and the Zika Virus. Normal detection of these biological agents requires multiple lab processes. This project aims to develop a fully integrated lab-on-a-chip device to accomplish this.

Quantification of Atherosclerosis

Atherosclerosis and subsequent cardiovascular disease causes nearly one-third of all deaths in the world. Unfortunately, atherosclerosis commonly remains asymptomatic for decades, and is properly diagnosed only after a severe, life-threatening cardiac event. Thus, a portable, low‐cost tattoo‐based biosensor for the non‐invasive self‐diagnosis and quantification of atherosclerosis was developed.

Cell Line to Search for Osteosarcoma Agents

Osteosarcoma, a bone tumor of childhood, is lethal when unresponsive to chemotherapy. ER stress response, a cell survival mechanism that is triggered upon exposure to stressors such as chemotherapy, is one of the ways a tumor becomes resistant to chemotherapy. This project explores novel methods of producing a noncytotoxic EGFP-ATF6 construct to signal Endoplasmic Reticulum stress response.

Translational Genomics of Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) does not respond to receptor targeted treatments because they do not possess the ligands to bind to these receptors. Thus, more research needs to be explored in terms of the translational modifications that genes undergo during this disease.

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