Rictor positively regulates B cell receptor signaling by modulating actin reorganization via ezrin

B cell receptor (BCR) signaling is vital for B cell development and function. When BCRs are cross-linked by antigens, it induces the conformational changes of signaling subunits immunoglobulin α chain (Igα) and immunoglobulin β chain (Igβ). The conformational changes of Igα and Igβ lead to the phosphorylation of immunoreceptor tyrosine-based activation motif (ITAM) domains of Igα and Igβ.

Ribosome Traffic on mRNAs Maps to Gene Ontology: Genome-wide Quantification of Translation Initiation Rates and Polysome Size Regulation

The expression of genes can be considered as a two-stage process, beginning with transcription and the production of an mRNA, followed by translation of that mRNA into protein by the cell’s ribosome population. Gene expression must be tightly regulated to control protein composition, enabling the cell to rapidly respond to a wide range of environmental conditions. For this reason, cells exert fine control over gene expression, both at the transcriptional, and post-transcriptional level.

Uncovering Zika

This research focuses on creating a novel rapid diagnostic test for Zika Virus NS1 protein using nanoribbon microfluidics.

Pancreatic Cancer Cells during Metastatic Progression

Our research focused on the detection of premalignant pancreatic cancer via computational analysis of serum proteomic profiles.

Post-MI Cardiac Tissue Engineering

In this study, the author engineers novel gelatin-NIPAM-graphene hydrogels and new, powerful computational tools to enhance precision cardiovascular medicine. Engineering Injectable, Conductive Hydrogels doped with Graphene and Graphene Oxide Nanoparticles for Post-MI Cardiac Tissue Engineering and Robust Drug Discovery: A Computationally-Aided Investigation for Enhancing Therapeutic Efficacy

Tensile Properties, Collagen Content, and Crosslinks in Connective Tissues of the Immature Knee Joint

The major connective tissues of the knee joint act in concert during locomotion to provide joint stability, smooth articulation, shock absorption, and distribution of mechanical stresses [1]-[3]. These functions are largely conferred by the intrinsic material properties of the tissues, which are in turn determined by their biochemical compositions

Pharmacogenomic identification of small molecules for lineage specific manipulation of subventricular zone germinal activity

Controlling the fate of neural stem cells (NSCs) is a key therapeutic strategy in neuroregenerative medicine. The most promising and direct approach would be to use small molecules to promote the generation of a particular neural lineage, without the need to introduce complex genetic methods.

Smartphone-based Ophthalmic Screening for Glaucoma

Lumos can allow patients to quickly screen for glaucoma and detect the disease in its early stages. All the patient needs is a smartphone, and the app will identify the glaucoma risk rapidly and automatically.

Superfamily Assignments for the Yeast Proteome through Integration of Structure Prediction with the Gene Ontology

The yeast Saccharomyces cerevisiae is one of the most widely studied organisms, yet a large fraction of its proteins are of unknown structure and/or unknown function. Knowledge of the structure of a protein is critical to understand how it functions, and hence, a complete set of protein structures for yeast is desirable, but difficult to accomplish experimentally.

Understanding Patient-Derived Glioblastoma Multiforme Cells’ Proliferation

Glioblastoma multiforme (GBM) is the most common and aggressive type of primary brain tumor. Patients with GBM have a median survival of 15 months. Thus, treating GBM can be achieved by inhibiting the proliferation of the patient-derived cells using leaf extract of B. monnieri.

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