Stochastic assembly produces heterogeneous communities in the Caenorhabditis elegans intestine

The gut microbiome varies greatly between individuals, and this variation could have important health consequences. These differences may be due to deterministic differences such as genetic differences between individuals or differences in individual history and environmental exposure; stochasticity may also play a role in variation between individual communities.

Protein Oxidation Implicated as the Primary Determinant of Bacterial Radioresistance

The amount of DNA damage caused by a given dose of γ-radiation for resistant and sensitive bacteria is very similar. Yet, the range of ionizing radiation (IR) resistances is large, with a factor of 200 separating the most-resistant from the most-sensitive species. For example, Deinococcus radiodurans can survive levels of IR (10 kGy) that induce approximately 100 DNA double-strand breaks (DSBs) per genome, whereas Shewanella oneidensis is killed by levels of IR (0.07 kGy) that result in less than 1 DSB per genome.

Phage Encoded H-NS: A Potential Achilles Heel in the Bacterial Defence System

Phage, viruses that infect bacteria and archaea, play a fundamental role in the environment through predation and lateral gene transfer. Uncultured environmental phage have been most extensively studied in marine ecosystems where they have been demonstrated to affect oceanic biogeochemistry.

Living Bacterial Sacrificial Porogens to Engineer Decellularized Porous Scaffolds

Porous materials are of scientific and technological interest and find broad applications in multiple areas such as storage, separation, catalytic technologies as well as emerging microelectronics and medicine

History of Antibiotic Adaptation Influences Microbial Evolutionary Dynamics During Subsequent Treatment

Antibiotic resistance is a growing healthcare concern whereby bacterial infections are increasingly difficult to eradicate due to their ability to survive antibiotic treatments [1]. There have been reported cases of resistance for nearly every antibiotic we have available [2]. Coupled with the fact that the antibiotic discovery pipeline has slowed over the past few decades [3], there is a dire need to find better treatment strategies using existing antibiotics that can slow or even reverse the development of resistance.

CRISPR Inhibition of Prophage Acquisition in Streptococcus Pyogenes

During evolution, bacteria acquired new traits primarily by horizontal gene transfer (HGT) as a key driving force for expressing novel pathogenic properties, new colonization niches as well as metabolic adaptations [1], [2], [3], [4], [5]. Conjugation, transduction and transformation are the major mechanisms for HGT. The contributions and the impact of each mechanism are variable among species [6].

Antibiotic Exposure Perturbs the Gut Microbiota and Elevates Mortality in Honeybees

Gut microbial communities influence animal health in many ways, including synthesis of vitamins, digestion of food, defense against pathogens, and modulation of behavior, development, and immunity [1]. The gut microbial community can be disturbed by several factors: one of the most potent sources of disturbance for humans and domesticated animals is antibiotic treatment, which can severely alter community size and composition.

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