Multidrug Resistant Superbugs

Antibiotics have been extensively used to treat patients with infectious diseases for the last 70 years. As these drugs have been used widely for long time, the organisms the antibiotics are designed to kill have adapted to them, making the drugs less effective. This can be prevented through selective separation, identification and eradication using fluorescent, magnetic multifunctional carbon dots.

Summary of Research

Antibiotics have been extensively used to treat patients with infectious diseases for the last 70 years. As these drugs have been used widely for long time, the organisms the antibiotics are
designed to kill have adapted to them, making the drugs less effective. As per Center for Disease control and Prevention (CDC) each year in the United States, at least 2 million people become infected with bacteria that are resistant to antibiotics and at least 23,000 people die each year as a direct result of these infections. Blood stream infection or sepsis by superbugs is one of the major health problems which has mortality rate of over 40%. High mortality rate is mainly due to the absence of technology available in clinics which can rapidly detect and identify bacteria from clinical blood sample in early stages of infection. At present the bacterial blood cultures and susceptibility testing are used in the clinic to find the drug that many be most effective in treating.

The whole process requires several days to obtain accurate results, as result, patient are treated with broad spectrum of antibiotics. This not only inadequate for patients but also encourages antibiotic resistance. Hence there is an urgent need for the new technology which has ability to rapidly diagnose drug resistance bacteria in a point-of-care setting. This work reports newly developed multicolor fluorescent carbon dots conjugated-magnetic nanoparticles are capable of selective separation and accurate identification and killing of superbugs from infected blood.

In addition, pardaxin antimicrobial peptide attached multicolor fluorescent magneto-carbon dots are designed as superbugs are resistant to antibiotics available in the market. Results indicates that by combining pardaxin antimicrobial peptides with fluorescent magneto-carbon dot nanoparticles, one can develop a novel multifunctional material which has great potential for an accurate identification, selective separation, and effective killing of multi drug resistance superbugs in clinics.

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Multidrug Resistant Superbugs

Antibiotics have been extensively used to treat patients with infectious diseases for the last 70 years. As these drugs have been used widely for long time, the organisms the antibiotics are designed to kill have adapted to them, making the drugs less effective. This can be prevented through selective separation, identification and eradication using fluorescent, magnetic multifunctional carbon dots.

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