Oral Squamous Cell Carcinoma (OSCC) is a cancer of the mouth epithelium with an annual incidence rate in the US of nearly 48,000 cases annually and a 5-year survival rate of only 65%. Cancer stem cells (CSCs) are believed to be responsible for progression of OSCC. The project’s main goal is to observe the effect of Wnt/β-catenin signaling inhibition on oral squamous cell carcinoma.
Osteosarcoma, a bone tumor of childhood, is lethal when unresponsive to chemotherapy. ER stress response, a cell survival mechanism that is triggered upon exposure to stressors such as chemotherapy, is one of the ways a tumor becomes resistant to chemotherapy. This project explores novel methods of producing a noncytotoxic EGFP-ATF6 construct to signal Endoplasmic Reticulum stress response.
Global warming is a significant threat to modern society caused by the burning of fossil fuels in order to meet everyday energy requirements. Renewable clean energy solutions such as solar and wind power are not as high-producing as carbon-based sources, but hydrogen-based electric energy is a viable alternative. This project focuses on finding alternatives to platinum for proton exchange membrane fuel cells.
The study’s objective was to design, build, and test a full-scale, self-powered solar tracking mechanism incorporating a damper system to reduce wind flutter.
RNA-based viruses and bacteria have been sources of large-scale epidemics and pandemics, most notably Ebola, SARS, influenza, hepatitis C, HIV, and the Zika Virus. Normal detection of these biological agents requires multiple lab processes. This project aims to develop a fully integrated lab-on-a-chip device to accomplish this.
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